• Open cohorts: NTRK fusions (all tumor types) and ROS1 fusions (all tumors except NSCLC)
• Entrectinib PO 600 mg daily

• HCC
• HR+ Breast cancer
• Cutaneous squamous cell carcinoma
• Basal cell carcinoma

 TVEC intrahepatic Q3W - Pembrolizumab Q3W IV 

• CAR-T cells will be administered with the first 3 cycles of FOLFIRI. 
• Hospitalization of 4 days after CAR-T administration required

• Exclusion: NSCLC with EGFR mutation
• Afatinib 40mg/day with increase to 50 mg.

AMG404: A Phase 1 study with AMG 404 (a PD-1 antibody) in patients with advanced solid tumors

• Melanoma
• SCLC
• NSCLC PD-L1 +
• HNSCC PD-L1 +
• Urothelial PD-L1 +
• Gastric/GEJ adone PD-L1 +
• Esophageal, squamous, PD-L1 +
• Cervical PD-L1 +
• HCC
• Merkel Cell Carcinoma
• SCC of the skin
• RCC, clear cell
• Undifferentiated pleiomorphic/malignant fibrous histiocytoma
• Poorly differentiated and/or dedifferentiated liposarcoma
• Alveolar Soft Tissue Sarcoma
• Angiosarcoma
• Thymic carcinoma
• Nasopharyngeal carcinoma, EBV positive
• Mesothelioma
• MSI-H or MMR-deficient tumors

• AMG 404 IV Q4W

• Archival tissue <1y old or fresh biopsy

CVPM087A2101: Phase Ib study of gevokizumab in combination with standard of care anti-cancer therapies in patients with metastatic colorectal cancer, gastroesophageal cancer and renal cell carcinoma

• Esophageal (Closed)
• Renal cell
• CRC

• Esophageal: 2L (Closed)
• Renal cell: 2-3L
• CRC: 1-2L

• Esophageal: prior fluoropyrimidine and platinum. Study treatment: gevokizumab + paclitaxel + ramucirumab. --> Closed
• Renal cell: prior anti-angiogenic therapy with radiographic progression during this treatment. Study treatment: gevokizumab + carbozantinib.
• CRC 1L: prior adjuvant is allowed if >= 6 months ago. Study treamtent: gevokizumab + mFOLFOX + bevacizumab.
• CRC 2L: prior fluoropyrimidine and oxali. Study treatment gevokizumab + FOLFIRI + bevacizumab.

MiMe-A: Multiorgan Metabolic imaging response assessment of Abemaciclib

• Esophageal squamous cell carcinoma --> 4 slots

AMG510: Phase 1/2 open label study with AMG510 monotherapy in subjects with advanced solid tumors with KRAS p.G12C mutation

• KRAS p.G12C mutation
• CRC: progression after 5-FU, oxaliplatin and irinotecan --> Closed
• NSCLC: progression after anti-PD1/anti-PDL1 AND/OR platinum-based combination therapy AND targeted therapy. Not more than 3 prior lines of therapy. --> Closed
• Solid: progression after 1st line or ineligible for 1st line treatment --> Open

Open

NCT03600883

RAGNAR: A Phase 2 Study of Erdafitinib in Subjects With Advanced Solid Tumors and Selected FGFR Gene Alterations

• FGFR mutations and FGFR fusions (NO amplifications!)
• Central testing allowed for:
•      Glioblastoma
•      Gliomas
•      SCCHN
•      Sarcoma
•      Endometrial
•      Cervix
•      Ovarian
•      NSCLC
•      RCC
•      Esophageal
•      Gastric
•      Breast: only HR+
•      HCC
•      Pancreatic
• Oral medication

NCT04083976

KISIMA-01: Phase Ib Study to evaluate the safety, tolerability and anti-tumor activity of ATP128, with or without BI 754091 in patients with stage IV CRC

• Ongoing PR or SD after completion of 1st line SOC therapy (min. 6 months) 
• 1 liver lesion amenable to repeated biopsy
• ATP128: chimeric recombinant protein vaccine
• BI754091: anti-PD1

NCT04046445

BLU-667: A Phase 1/2 study of the highly-selective RET inhibitor, BLU-667, in patients with thyroid cancer, NSCLC and other advanced solid tumors

• Other solid tumors (except NSCLC): RET fusion

• Other solid tumors (except NSCLC): previously treated with SOC therapy

• Oral medication 

NCT03037385

MIV-818: A Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of MIV-818 in Patients with Liver Cancer Manifestations

• Oral medication 
• Mandatory on-treatment liver biopsy 
• Child-Pugh A score 

NCT03781934

MCLA-145-CL01: A Phase 1, Open-label, Dose-escalation study of MCLA-145 in participants with advanced or metastatic malignancies 

• Dual CD137 + Anti-PD-L1 antibody 
• Prior anti-PD-1 is allowed (max 1 line)
• Mandatory pre- and on-treatment biopsy
• Specific inclusion criteria for TNBC, melanoma, HNSCC and urothelial carcinoma

NCT03922204

SYD985.004:A Phase 1 study with the antibody-drug conjugate SYD985 in combination with Niraparib in patients with HER2-expressing locally advanced or metastatic solid tumors 

All solid tumors 

• SYD985 IV Q3W + Niraparib oral 
• HER2 tumor status at least 1+ assessed by IHC

NCT04235101

GO40987: A phase I, multicenter, open-label, preoperative, short-term window study of GDC-9545 in postmenopausal women with Stage I-III operable, estrogen receptor-positive breast cancer.

Breast

• ER+/Her2-negative unilateral breast cancer eligible for primary surgery
• Primary tumor >= 1.5 cm
• Postmenopausal women 
• Oral medication QD for 15d prior to surgery 

NCT03916744

INCB86550-102: A Phase 1 study with INCB086550 in patients with advanced solid tumors

• MSI-H/d MMR tumors
• Cutaneaous squamous cell carcinoma
• HCC
• PDL-1 positive esophageal squamous cell carcinoma
• Merkel cell carcinoma
• SCLC
• PDL-1 positive mesothelioma
• Any PDL-1 amplified tumor (9p24.1)
• Nasopharyngeal carcinoma
• Cyclin-dependent kinase 12 mutated tumors (loss of function, not amplification)
• Basal cell carcinoma (unresectable or metastatic)
• RCC with sarcomatoid features
• Clear cell ovarian or endometrial carcinoma
• DNA polymerase epsilon mutated tumors (P286R and V411L)

Other tumor types with approval of Medical Monitor

• Progressed after SOC or intolerant/ineligible for SOC
• No limit to number of prior treatment regims 

• Oral anti-PDL-1
• Mandatory screening + on treatment biopsy 

NCT03762447

eNRGy: Full molecular testing by RNA/DNA next generation sequencing to detect RNA/DNA alterations (including NRG1 fusions) 

• Sponsor: Merus 
• Whole genome sequencing of RNA/DNA (200 genes) 
• ≤ 60 years old at time of diagnosis
• KRAS mutated NOT eligible 
• In case of NRG1 fusion, possibility to enter Early Access Program examining the safety and efficacy of Zenocutuzumab (www.nrg1.com)

GO41864: A phase Ib dose-escalation and dose-expansion study evaluating the safety, tolerability, pharmacokinetic, and efficacy of venetoclax in combination with atezolizumab, carboplatin, and etoposide in patients with untreated extensive-stage small cell lung cancer.

• Arm A: Maintenance: after 4-6 cycles carboplatinum + etoposide +/- atezolizumab for which SD or PR
• Arm B: Induction + maintenance: 1st line -> hold 

• Induction with carboplatinum + etoposide + atezolizumab + venetoclax -> hold
• Maintenance with atezolizumab + venetolax 
• Venetoclax = oral 

BOT112-02: Phase IIa open-label clinical study of intratumoural administration of BO-112 in combination with pembrolizumab in subjects with liver metastasis from colorectal cancer or gastric/gastro-oesophageal junction cancer.

• Arm A: CRC
• Arm B: GC/GEJ

• ARM A: >= 3L
• Arm B: >=2L 

• Pembrolizumab IV Q3W + BO-112 intrahepatic Q3W
• Primarily liver disease
• At least 1 liver m+ of >=20mm suitable for percutaneaous, intra-tumoral injection
• Mandatory on-study biopsy 
• anti-PD(L)-1 naive 

Precision-2 olaparib: Efficacy of Olaparib in advanced cancers occurring in patients with germline mutations or somatic tumor mutations in homologous recombination genes.

• HRD mutated tumor 
• except ovarian and BRCA1/2 mutated breast/pancreas

• Olaparib 300mg BID

MATTERS: A mono-centric, first in-human (FIH), safety and preliminary efficacy study of (neo)adjuvant, model-based, whole-body hyperthermia (WBHT) treatment in advanced solid cancer patients or stage IV (TxNxM1) metastatic pancreatic adenocarcinoma patients

• Cohort A1: Three patients with advanced solid cancer will be subjected to repetitive hyperthermia starting with 2 hours (day 1), 4 hours (day 8) and 6 hours (day 15)
• Cohort A2: The highest whole-body hyperthermia duration with acceptable side effects from cohort A1 will be applied to three additional patients with advanced solid cancer, once a week and for 15 days in total
• Cohort B1: Three pancreatic cancer patients will be subjected to repetitive hyperthermia starting with 2 hours (day 1), 4 hours (day 8) and 6 hours (day 15) using the device and in combination with the standard of care chemotherapy (FOLFIRINOX, FOLFOX, gemcitabine/nab-paclitaxel or gemcitabine alone).
• Cohort B2: The highest whole-body hyperthermia duration with acceptable side effects from cohort B1 will be applied in combination with chemotherapy (FOLFIRINOX, FOLFOX, gemcitabine/nabpaclitaxel or gemcitabine alone) to three additional pancreatic cancer patients, once a week and for 15 days in total

INCB99280-112: A Phase 1 Study Exploring the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Select Advanced Solid Tumors

• MSI-high or MMR-deficient tumors (all types except brain)
• Cutaneaous squamous cell carcinoma
• HCC
• DL-1 positive esophageal squamous cell carcinoma
• Merkel cell carcinoma
• SCLC
• PDL-1 positive mesothelioma
• Any PDL-1 amplified tumor (9p24.1)
• Urothelial carcinoma with CPS >= 10%
• Nasopharyngeal carcinoma
• Cyclin-dependent kinase 12 mutated tumors (loss of function, not amplification)
• Basal cell carcinoma (unresectable or metastatic)
• RCC with sarcomatoid features
• Clear cell ovarian or endometrial carcinoma
• DNA polymerase epsilon mutated tumors (P286R and V411L)
• Other tumor types with approval of Medical Monitor

• Progressed after SOC or intolerant/ineligible for SOC
• No limit to number of prior treatment regimens, but maximum 1 line of immune therapy
• Prior anti-PD-L1 is exclusion

• Oral anti-PD-L1
• Mandatory screening + on treatment biopsy

EZH-1201: A Phase I, Open-label Multi-dose Pharmacokinetic and Safety Study of Oral Tazemetostat in Subjects with Moderate and Severe Hepatic Impairment with Advanced Malignancies.

All tumortypes with:

• Moderate hepatic impairment -> slots
• Severe hepatic impairment -> hold 

• Prior SOC 

• Moderate hepatic impairment: bilirubin from 1.5 to 3 x ULN
• Severe hepatic impairment: bilirubin >= 3 x ULN
• Oral tazemetostat
• Intensive PK sampling

NCT04241835

BP42169: An Open-Label Phase 1 Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7293583, A TYRP1-Targeting CD3 T-Cell Engager, in Participants With Metastatic Melanoma

TYRP-positive melanoma

• Progressed after SOC or intolerant/ineligible for SOC
• No limit to number of prior treatment regimens

• TYRP-prescreening on archival/fresh tissue
• RO7293583 IV Q3W with hospitalization after 1st administration
• Mandatory screening + on treatment biopsy

NCT04551352

ARRAY 818-103: An Open-label Phase 1 Study to Evaluate Drug-Drug Interactions of Agents Co-Administered With Encorafenib and Binimetinib in Patients With BRAF V600-mutant Unresectable or Metastatic Melanoma or Other Advanced Solid Tumors

BRAF V600E/V600K mutated solid tumors

• Progressed after SOC or intolerant/ineligible for SOC
• No limit to number of prior treatment regimens
• Prior BRAF/MEK inhibitor is permitted, except as last line

• Arm 1: CYP probe cocktail (oral) + encorafenib and binimetinib
• Arm 3: modafinil (oral) + encorafenib and binimetinib
• After drug-drug interaction period (first 28 days), patient proceeds with encorafenib and binimetinib

NCT03864042

TRIDENT-1: A Phase 1/2, Open-Label Study of the Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of TPX-0005 in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements (TRIDENT-1)

• NSCLC with ROS1 rearrangements
• Solid tumors with NTRK rearrangements

• NSCLC: maximum 2 prior TKI’s, maximum 1 prior line of chemotherapy/immune therapy
• Solid: maximum 2 prior TKI’s, no limit on prior lines of chemotherapy/immune therapy

• Oral repotrectinib = novel TKI
• Different cohorts according to prior TKI and chemo/immune therapy

NCT03093116

JZLA (EMBER): A Phase 1a/1b Study of LY3484356 Administered as Monotherapy and in Combination With Anticancer Therapies for Patients With ER+ Locally Advanced or Metastatic Breast Cancer and Other Select Non-Breast Cancers

• Part A: ER+/HER2- mBC
• Part B: ER+/HER2- mBC
• Part C: ER+/HER2+ mBC
• Part D: ER+ endometroid endometrial cancer

• Part D: ER+ endometroid endometrial cancer
• Part B: prior CDK4/5i, maximum 2 prior lines for advanced disease with only 1 prior hormone therapy
• Part C: at least 2 prior HER2 directed regimens for advanced disease, prior trastuzumab & pertuzumab & TDM-1, no prior CDK4/6i, no prior fulvestrant
• Part D: progression on platinum-based SOC, no prior aromatase inhibitor, no prior fulvestrant

• LY3484356 (oral) monotherapy or in combination with other drugs
• Part A: LY3484356 + abemaciclib +/- aromatase inhibitor
• Part B: LY3484356 monotherapy
• Part C: LY3484356 + trastuzumab +/- abemaciclib
• Part D: LY3484356 +/- abemaciclib 

NCT04188548

• Stage III
• max. 12 months on adjuvant HT
• ARM A: Ribociclib 400 mg + Letrozole (+/- Goserelin)
• ARM B: Letrozole (+/- Goserelin)

HR + and HER2 low or - :

- IHC 2+/ISH-

- IHC 1+/ISH- or untested

- IHC 0/ISH- or untested

• HER2 central confirmation necessary
• progressed on min. 2 prior lines ET for mBC
• no prior chemotherapy for aBC/mBC
• no history of (non-infectious) ILD/pneumonitis

• Molecular study, no study treatment
• Blood samples every 6 months and at progression
• Biopsy after first or second progression and prior to next line of therapy

• Recurrence/PD on or within 12m of end of adjuvant AI or PD while on AI for aBC/mBC.
• max. 2 prior ET for aBC/mBC
• max. 1 prior chemotherapy for aBC/mBC
• No prior Fulvestrant, SERDs, AKT, PI3K, and/or mTOR inhibitors
• prior CDK4/6 inhibitors allowed (max. 50% of target)
• Measurable disease per RECIST 1.1 or lytic bone only disease
• FFPE tumour sample available

• PIK3CA mutant
• PD on or within 12 months of completing adjuvant treatment
• Measurable disease per RECIST 1.1
• GDC-0077/Placebo + Fulvestrant + Palbociclib

• 1L chemo
• Cohort 1: TNBC (nivolumab/pembroluzimab/atezoluzimab + tesetaxel)
• Cohort 2: >= 65 years HR+ (tesetaxel) --> Closed
• Tesetaxel = oral taxane therapy
• Archival tumor tissue available

• unilateral, (T1cN1; T2N1; T3N0) or locally advanced non inflammatory (T3N1; T4; any T and N2-3) or inflammatory (T4d any N)
• mandatory biopsy before Cycle 2
• baseline LVEF > 55%
• ARM A: neo-adj. chemotherapy + trastuzumab + pertuzumab; adjuvant trastuzumab + pertuzumab
• ARM B: neo-adj. chemotherapy + trastuzumab + pertuzumab + atezolizumab; adjuvant trastuzumab + pertuzumab + atezolizumab

• new diagnosis of FIGO IB-IVB or central recurrent invasive
• amenable for biopsy
• Ca/VitD supplements +/- denosumab 

FUCHSIA: An open-label, single arm, prospective, multi-center, tandem two stage designed, phase II study to evaluate the efficacy of Fulvestrant in women with recurrent/metastatic estrogen receptor positive gynecological malignancies

• Recurrent or metastatic low grade uterine sarcomas, low grade endometrial carcinomas, sex cord tumors and low grade serous ovarian cancer
• Estrogen-receptor (ER) positive
• Hormonal therapy must have lasted for at least 3 months
• Fulvestrant treatment 

• Aspirin versus placebo
• Ro resection
• >45year
• stage II-III

SPOTLIGHT: A Double-Blind, Randomized, efficacy Study of Zolbetuximab (IMAB362) Plus mFOLFOX6 Compared with Placebo Plus mFOLFOX6

• Claudin 18.2-Positive on central lab
• HER2-Negative
• Locally Advanced Unresectable or Metastatic Adenocarcinoma

CAIRO 5: Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases

• Available KRAS/BRAF status mutation prior randomisation
• RAS WT: Folfox/folfiri + beva versus pani 
• RAS MUTANT: Folfox/folfiri versus folfoxiri + beva Liver expert panel will evaluate resectability status

TOPGEAR: Trial of Preoperative Therapy for Gastric and Esophagogastric Junction Adenocarcinoma

• Randomisation between preoperative chemo alone versus chemoradiation
• Chemo: ECF or ECX or EOX or FLOT
• Pre-op CRT: 5FU or capecitabine 

DZB-CS-301: A pivotal study of derazantinib in patients with inoperable or advanced intrahepatic cholangiocarcinoma

Intrahepatic CholangioCA

• Pre-screening on FGFR2 gene fusions (closed) or FGFR2 gene mutations or amplifications who received at least one prior regimen of systemic therapy

TIGeR-PaC: Intra-arterial Gemcitabine vs. Continuation of IV Gemcitabine plus Nab-Paclitaxel following Induction with sequential IV Gemcitabine plus Nab-Paclitaxel and Radiotherapy. 

Unresectable Locally Advanced Pancreatic Cancer

• Histologically or Cytopathology confirmed pancreatic adenocarcinoma
• Anatomy suitable for IA delivery of gemcitabine to the intended tumor site
• Locally advanced, unresectable disease at screening and prior to randomization, as defined by NCCN criteria
• initial diagnosis within 6 weeks of consent

LEAD-IN FOLICOLOR Trial: Detection of progressive disease in metastatic colorectal cancer patients by NPY methylation in liquid biopsies.

Unresectable metastatic colorectal cancer 

PROMETCO

Metastatic colorectal cancer

CL3-95005-007

• Arm 1: Trifluridine/tipiracil (oral) mono

   

• Arm 2: Trifluridine/tipiracil with bevacizumab
• Randomized (1:1), open-label, phase III study 
• Known RAS status
• Progression or intolerance on maximum 2 prior chemotherapy regimens
• Prior treatment regimens must have included a fluoropyrimidine, irinotecan, oxaliplatin, an anti-VEGF and/or an anti-EGFR monoclonal antibody for RAS wild-type

MOUNTAINEER

Unresectable or metastatic Colorectal Cancer

• Arm 1: Tucatinib (oral) + Trastuzumab 

• Arm 2: Tucatinib mono 

• Randomized (1:1), open label, phase II study 

• Cross-over is possible 

• Must have progressed on or been intolerant to treatment with 5-FU, oxaliplatin, irinotecan, anti-VEGF. Previously treated with anti-HER2 target is exclusion.

• RAS wild-type, HER 2+ 

• Be able to swallow pills 

YO42137

• Arm A: Tiragolumab + atezolizumab
• Arm B: Tiragolumab + placebo 
• Arm C: placebo + placebo 
• Randomized (1:1:1), double-blind, phase III study 
• Stage II-IVA esophageal squamous cell (8th edition) 
• Received at least 2 cycles platinum-based chemo and radiation consistent with definitive treatment without evidence of disease progression 
• Randomization must occur with 1-63 days after last dose definitive concurrent chemo radiotherapy  

QBGJ398-301 (PROOF trial)

• Arm 1: Infigratinib (oral) 
• Arm 2: Gemcitabine + Cisplatin 
• Randomized (1:1), open label, phase III study 
• FGFR2 gene fusion/translocation  

MK3475-966

Advanced and/or unresectable biliary tract carcinoma

• Arm A: Pembrolizumab + gemcitabine/cisplatin 
• Arm B: placebo + gemcitabine/cisplatin
• Randomized (1:1), double-blind, phase III study 

MK7339-003

Unresectable or metastatic colorectal cancer without progression on 1ste line FOLFOX

1

• Arm 1: Olaparib (oral) + Bevacizumab
• Arm 2: Olaparib mono 
• Arm 3: 5-FU + bevacizumab 
• Randomized (1:1:1), open-label, phase III study 
• Has not progressed after completing at least 6 prior induction cycles of FOLFOX + bevacizumab and can no longer tolerate oxaliplatin  

FRESCO-2

>3

• Arm 1: Fruquintinib (oral) + BSC 
• Arm 2: placebo + BSC 
• Randomized (2:1), double-blind study, phase III study 
• Must have progressed on or been intolerant to treatment with TAS-102 and / or regorafenib, 5-FU, oxaliplatin, irinotecan, anti-VEGF, if RAS wild-type an anti-EGFR.

D-US-60010-001 (NAPOLI-3)

• Arm 1: irinotecan liposome injection + oxaliplatin + 5-FU/LV
• Arm 2: nab-paclitaxel + gemcitabine  
• Randomized (1:1), open-label, phase III study 
• Initial diagnosis < 6 weeks prior screening 

• Historical or fresh biopsy required 
• ARM A treatment naïve triptorelin + bicalutamide or standar chemotherapy
• ARM B pretreated: triptorelin + bicalutamide
• Cross-over from Arm A SOC to Arm B possible

SCCHN: 

• oral cavity 
• oropharynx
• hypopharynx
• larynx 

• Fresh tumor core biospy, centrally assessed
• Cohort I2: Pretreated with prior PD(L)1
• Cohort B1: p16 negative and EGFR amplification/mutation or PTEN high or HER2 amplification/mutation
• Cohort B2: p16 negative and cetuximab naïve
• Cohort B3: p16 negative and CCND1 amplification
• Cohort B4: p16 negative and ‘platinum-sensitive’
• Cohort B5: p16 positive oropharyngeal cancer
• Cohort B6: FGFR1/2/3 mRNA overexpression
• Cohort I2: monalizumab + durvalumab vs. physician's choice
• Cohort B1 + B2: afatinib vs. physician's choice
• Cohort B3: palbociclib vs. physician's choice
• Cohort B4 + B5: Niraparib
• Cohort B6: rogaratinib

SCCHN Oropharynx HPV16+

• 1st line: tumors express PD-L1
• 2nd line: progression on or after platinum
• fresh biopsy, if possible
• no prior anti-PD(L)1

Thyroid (papillary or follicular)

• Up to two prior VEGFR-targeting TKI agents are allowed
• Previously treated with or deemed ineligible for Iodine-131
• QTcF < 500 ms

SCCHN 

• oral cavity
• pharynx
• larynx
• sinonasal
• nasopharyngeal
• unknown primary

HN9: Randomized Phase II study of Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy followed by Adjuvant Durvalumab vs Durvalumab + Radiotherapy followed by Adjuvant Tremelimumab and Durvalumab in Intermediate Risk HPV-Positive Locoregionally Advanced Oropharyngeal Squamous Cell Cancer

SCCHN Oropharynx p16+

• No induction chemotherapy allowed
• Intermediate risk:
• - T1-2 N1 (smoking ≥ 10 pack years) 
• - T3 N0-N1 (smoking ≥ 10 pack years)
• - T1-3 N2 (any smoking hx) 
• - Arm A: Cisplatin + RT
• - Arm B: Durvalumab + RT + adjuvant Durvalumab
• - Arm C: Durvalumab + RT + adjuvant Durvalumab-Tremelimumab --> closed

• Topotecan and Cyclophosphamide (TC)
• High dose Ifosfamide (IFOS)

• Estimated to start with chemoradiation ≥ 28 days and ≤ 49 days following surgical resection
• No Prior radiation or chemotherapy
• Total or subtotal resection
• No corticosteroid treatment ≤ 1 week before
• WT1 mRNA-loaded DC vaccination + CRT (temozolomide)

• Complete resection done
• Commence radiotherapy between within 12 weeks of surgery

• ≥ 2 bone metastases
• Ongoing androgen deprivation therapy (ADT) with luteinizing hormone-releasing hormone (LHRH) agonist or antagonist or bilateral orchiectomy
• Prior docetaxel is permitted under the following conditions: started within 2 months of ADT initiation, given for a maximum of 6 cycles and progression after 6 months of the last dose of docetaxel.
• ARM A: Enzalutamide
• ARM B: Ra223 + Enzalutamide

• No previous exposure to cabozantinib prior to inclusion 
• 3rd line --> Closed

• T2, T3 or T4a, Nx, N0, N1 or N2, M0
• Cisplatin eligible: R1:1 MVAC+Avelumab or Cis-Gem+Avelumab
• Cisplatin ineligible: R1:1 Paclitaxel-Gem+Avelumab or Avelumab

• Cutaneous melanoma
• Metastases solely confined within the SN
• CLND or serial nodal observation according to patient decision

• Unresectable stage IIIB-D or IV
• No uveal or ocular melanoma 

• Unresectable stage IIIC-D or IV
• No uveal or ocular melanoma
• Cross-over possible

• Resectable stage IIA (≥ 4cm) to IIIB (T3N2)
• Tissue to be submitted before randomization 

• all subtyes. 
• cT1-3 N0-2 M0.
• 1:1 randomisation to P/D followed by adjuvant 3 cycles platinum-pemetrexed versus neoadjuvant 3 cycles platinum-pemetrexed followed by P/D.

• early referal (at least during second cycle chemo) required.
• all sybtypes.
• 1:1 radomisation MesoPher plus BSC versus BSC alone.
• no known allergy to shellfish.
• no history of auto-immune diseases.

• all subtypes.
• no progression after 4-6 cycles platinum-based chemotherapy.
• randomisation within 60 days from last dose of chemotherapy.              
• nintedanib or placebo oral twice daily

• at least one previous line of platinum-based chemotherapy.
• no history of myasthenia or auto-immune disease.
• nivolumab q2w.

• EGFR activating mutation

• MET amplification in TBx, (central or local FISH), or in LBx (central)
• Prior objective clinical benefit to previous osimertinib 
• Radiologic disease progression to previous osimertinib
• Tepotinib + osimertinib or Tepotinib monotherapy

• Arm A: Pralsetinib PO

• Arm B: Carboplatin or cisplatin/pemetrexed; Pembrolizumab/carboplatin or cisplatin/pemetrexed; Carboplatin or cisplatin/gemcitabine 

• Tissue to be submitted (archived/fresh)

• Crossover possible after central confirmed PD

• CEACAM5 >=2+ (centrally assessed)
• prior platinum and immune checkpoint inhibitor
• no previous corneal disorder
• contact lenses are not permitted

• Only cohort for NTRK fusions still open
• Entrectinib PO 600 mg daily

NSCLC

stage IIIb-IV

• KRAS p.G12C mutation centrally confirmed

• Prior platinum-based doublet and checkpoint inhibitor for advanced or metastatic disease, either as one line or as individual lines

NCT04303780

All solid tumors 

• Dual CD137 + Anti-PD-L1 antibody
• Prior anti-PD-1 is allowed (max 1 line) 
• Mandatory pre- and on-treatment biopsy 
• Specific inclusion criteria for TNBC, melanoma, HNSCC and urothelial carcinoma

NCT03922204

Extensive stage-SCLC

• Arm A: Maintenance: after 4-6 cycles carboplatinum + etoposide +/- atezolizumab for which SD or PR
• Arm B: Induction + maintenance: 1st line -> hold 

• Induction with carboplatinum + etoposide + atezolizumab + venetoclax -> hold
• Maintenance with atezolizumab + venetolax 
• Venetoclax = oral 

NCT04422210

All solid tumors 

• SYD985 IV Q3W + Niraparib oral 
• HER2 tumor status at least 1+ assessed by IHC

NCT04235101

NSCLC stage III-IV

• BMI < 20
• weight loss of >2% within 6 prior months
• problems with appetite/eating associated with cancer
• no reversible cause of reduced food intake
• on or off anti-cancer treatment

NCT03743064 

NSCLC

• MET/CEP7 ratio = 2 via FISH (local) or c-Met+ assessed by IHC (central)
• prior chemotherapy and prior immune checkpoint (N/A if mutant) and prior TKI (sequential lines count as 1)
• pre-screening can be done during prior line
• Non-Sq EGFR WT c-MET high Stage 1
• Non-Sq EGFR WT c-Met intermediate Stage 1
• Non-Sq EGFR Mut c-MET high Stage 1 -> Closed 
• Non-Sq EGFR Mut c-MET intermediate Stage 1
• Squamous-> CLOSED

NCT03539536